I drink a great deal of coffee. It's always nice to see a study that promotes the health benefits of coffee even though I suspect the hidden hand of "The Coffee Industry". The No Agenda Show does a great job at looking the behind the scenes production of our news, media, and information world that we live in. I think sometimes they are way off base but almost always offer something that makes far more sense to me than what is presented in the more mainstream sources of information.
Just for kicks googled caffeine acetylcholine interactions.
When you sleep, a natural sedative in your brain triggers a significant decrease in the acetylcholine levels in your central nervous system, the National Institute of Mental Health explains. Apparently, this drop in acetylcholine allows your brain to form the chemical associations that give you the ability to remember the individual words in your vocabulary. According to a 2008 study published in “Behavioral Brain Research,” when you drink caffeine, it can block the activity of the sedative that lowers your acetylcholine levels and trigger a subsequent abnormal increase in your central nervous system’s acetylcholine supply.
Caffeine is an alkaloid with a stimulant effect in the body. It can interfere in transmissions based on acetylcholine, epinephrine, norepinephrine, serotonin, dopamine and glutamate. Clinical studies indicate that it can be involved in the slowing of Alzheimer disease pathology and some other effects. The effects are not well understood. In the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), the two enzymes participating in cholinergic neurotransmission. A standard Ellman test with human AChE and BChE was done for altering concentrations of caffeine.